Alpha-Toxin of Clostridium perfringens Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens
AL Keyburn, SA Sheedy, ME Ford… - Infection and …, 2006 - Am Soc Microbiol
Infection and immunity, 2006•Am Soc Microbiol
The Clostridium perfringens alpha-toxin has previously been implicated as the major
virulence factor in necrotic enteritis in chickens, although definitive proof has not been
reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate
and shown to retain full virulence in a chicken disease model. These results demonstrated
that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in
chickens.
virulence factor in necrotic enteritis in chickens, although definitive proof has not been
reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate
and shown to retain full virulence in a chicken disease model. These results demonstrated
that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in
chickens.
Abstract
The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent chicken isolate and shown to retain full virulence in a chicken disease model. These results demonstrated that alpha-toxin is not an essential virulence factor in the pathogenesis of necrotic enteritis in chickens.
American Society for Microbiology以上显示的是最相近的搜索结果。 查看全部搜索结果